ISayensi eNgemva kweempawu zeNgcambu yeTurmeric ye-Anti-Cancer

I-Turmeric sisityalo esiye sasetyenziswa kangangeenkulungwane kumayeza esintu ngenxa yeenzuzo ezininzi zempilo. Enye yezinto eziphambili ezifunyenwe kwi-turmeric yi-curcumin, ebonakaliswe ukuba inezinto ezilwa ne-antioxidant kunye ne-anti-inflammatory. Nangona kunjalo, uphando lwakutsha nje luye lwafumanisa amandla engcambu ye-turmeric ekulweni nomhlaza.

I-Aogubio yinkampani ekhethekileyo eyenza kwaye isasaze izinto ezisebenza nge-pharmacologically, imathiriyeli ekrwada, kunye nezicatshulwa zezityalo. Njengenxalenye yoluhlu lwemveliso yabo, banikezela nge-turmeric root extract, eye yaqinisekiswa ngokwesayensi ukuba ineempawu ezichasene nomhlaza.

Umhlaza sisifo esibulalayo esichaphazela izigidi zabantu kwihlabathi liphela. Ibonakala ngokukhula okungalawulekiyo kunye nokwahlukana kweeseli ezingaqhelekanga emzimbeni. Unyango lwesintu lomhlaza, olufana nechemotherapy kunye nonyango lwemitha, ludla ngokuba neziphumo ebezingalindelekanga ezimandundu kwaye lunokungasebenzi kwezinye iimeko. Ngoko ke, kukho ukukhangela rhoqo kwiikhompawundi zendalo ezinokulwa ngokufanelekileyo nomhlaza kunye nemiphumo emincinci.

Izifundo ezininzi ngoku zidibanise ingcambu ye-turmeric kwiipropathi ezichasene nomhlaza. Uphando olupapashwe kwiphephancwadi elithi "Uphando lweCancer kunye noNyango" lubonise ukuba i-curcumin, inxalenye esebenzayo kwi-turmeric, inqanda ukukhula kweeseli zomhlaza. Ngokukodwa, i-turmeric root extract iboniswe ukuvimbela ukukhula kweeseli zomhlaza we-ovari kwii-hamsters zaseTshayina kwi-concentration ye-0.4mg / ml. Ikwabonisa iziphumo ze-cytotoxic kwi-lymphocytes kunye neeseli ze-lymphoma ze-Dalton, ebonisa amandla ayo njengonyango lweentlobo ezahlukeneyo zomhlaza.

Iziphumo ezichasene nomhlaza we-turmeric root extract zikholelwa ngokuyinhloko ngenxa yesithako esisebenzayo, i-curcumin. I-Curcumin ifunyenwe ukuba inqanda iindlela ezininzi zokubonisa iimpawu ezibandakanyekayo ekukhuleni kweeseli zomhlaza kunye nokuphila. Inokucinezela ukusebenza kwe-nuclear factor-kappa B (NF-kB), iprotein complex elawula ukudumba kwaye idlala indima ebalulekileyo kuphuhliso lomhlaza. Ngokunqanda i-NF-kB, i-curcumin inokuthintela ukubonakaliswa kwezakhi zofuzo ezibandakanyekayo ekuqhubekeni kwe-tumor.

Ngapha koko, i-curcumin ifunyenwe ibangela i-apoptosis, okanye ukufa kweseli ecwangcisiweyo, kwiiseli zomhlaza. I-Apoptosis yinkqubo yendalo esusa iiseli ezingaqhelekanga okanye ezonakalisiweyo emzimbeni. Iiseli zomhlaza zinomthamo ophantsi we-apoptosis, onegalelo ekukhuleni kwabo okungalawulekiyo. I-Curcumin inokubuyisela amandla eeseli zomhlaza ukuba zingene kwi-apoptosis, zithintele ngokufanelekileyo ukwanda kwazo.

Enye indlela i-curcumin eyenza ngayo imiphumo yokuchasana nomhlaza ngokumodareyitha kweenkqubo ze-epigenetic. I-Epigenetics ibhekisa kutshintsho kwimbonakalo yemfuza engabandakanyi utshintsho kulandelelwano lweDNA. Idlala indima ebalulekileyo ekuphuhliseni umhlaza kunye nenkqubela phambili. I-Curcumin ibonakaliswe ukuchaphazela ukubonakaliswa kweentlobo ezahlukeneyo zofuzo ezibandakanyekayo ekunyanzelweni kwe-tumor kunye ne-oncogenesis ngokuguqulwa kwe-epigenetic, njenge-DNA methylation kunye ne-histone acetylation.

Nangona iziphumo ezithembisayo malunga neempawu ezichasene nomhlaza we-turmeric root extract, uphando olongezelelweyo lusafuneka ukuze kuqondwe ngokupheleleyo iindlela zokwenza kunye nezicelo ezinokubakho kunyango lomhlaza. Izilingo zeklinikhi ziyaqhubeka ukuvavanya ukusebenza kunye nokhuseleko lwe-curcumin njengonyango lwe-adjuvant kwiindidi ezahlukeneyo zomhlaza.

Ukuqukumbela, i-turmeric root extract, ngokukodwa icandelo layo elisebenzayo i-curcumin, ibonise iimpawu ezichasene nomhlaza. I-Aogubio, inkampani ekhethekileyo ekuveliseni nasekuhanjisweni kwezinto ezisebenzayo ze-pharmacologically, inika i-turmeric root extract njengenye indlela yendalo ekulweni nomhlaza. Ngokukwazi ukuthintela ukukhula kweeseli zomhlaza, ukukhuthaza i-apoptosis, kunye nokulungelelanisa iinkqubo ze-epigenetic, i-turmeric root extract ibambe amandla amakhulu njengonyango olongezelelweyo kunyango lomhlaza. Nangona kunjalo, uphando olongezelelweyo kunye nezifundo zeklinikhi ziyimfuneko ukuphonononga ngokupheleleyo amandla alo kunye nokuqinisekisa ukusebenza kwayo kunye nokhuseleko.