ISayensi ngasemva kwe-N-Acetylcysteine: Iwuxhasa njani umsebenzi wokuphefumla oFanelekileyo

ISayensi ngasemva kwe-N-Acetylcysteine: Indlela exhasa ngayo umsebenzi wokuphefumla

Igama lemveliso:N-Acetylcysteine

Imbonakalo:Umgubo wekristale omhlophe

Yabelana ku:

Buza I-COA / MADS

Iinkcukacha zeMveliso

Ukuthumela ngenqanawa kunye nokuPakisha

Inkonzo ye-OEM

Ngathi

Iithegi zeMveliso

I-N-Acetylcysteine powder, eyaziwa ngokuba yi-NAC, i-antioxidant enamandla kunye ne-precursor ye-glutathione, i-molecule ebalulekileyo ekukhuseleni umzimba wethu kwizinto ezinobuthi. Nangona i-NAC isetyenziswe amashumi eminyaka njenge-agent ye-mucolytic, uphando olutshanje luye lwabonisa indima yalo ekuxhaseni umsebenzi wokuphefumula. Kule nqaku, siya kukhangela kwisayensi emva kwe-N-Acetylcysteine kunye nemiphumo emihle kwindlela yokuphefumula.

Ukuqonda indlela i-N-Acetylcysteine exhasa ngayo umsebenzi wokuphefumula, kufuneka sihlolisise iindlela ezisisiseko zempilo yokuphefumula. Inkqubo yokuphefumla iquka iindlela zethu zomoya, imiphunga, kunye nothungelwano oluntsonkothileyo lweeseli ezinoxanduva lokutshintshiselana ngegesi. Nangona kunjalo, ukuvezwa kwezinto ezingcolileyo, iintsholongwane, okanye iimeko ezithile zonyango kunokukhokelela kuxinzelelo lwe-oxidative kunye nokuvuvukala, ukuphazamisa umsebenzi wokuphefumula.

Kulapho i-N-Acetylcysteine ibonakalisa ukuba ingabalulekanga. Njenge-precursor ye-glutathione, isebenza njenge-antioxidant enamandla, i-neutralize i-radicals yamahhala eyingozi kunye nokunciphisa uxinzelelo lwe-oxidative. Ngokuzalisa amanqanaba e-intracellular glutathione, i-N-Acetylcysteine inceda ukugcina ibhalansi ethambileyo ye-antioxidants kwaye ikhusela inkqubo yokuphefumla kumonakalo.

Ngaphezu koko, i-N-Acetylcysteine ineempawu ze-mucolytic, oku kuthetha ukuba inceda ukudiliza kunye ne-mucus encinci kwi-airways. Oku kunenzuzo ngakumbi kubantu abaneemeko zokuphefumla ezingapheliyo, ezifana nesifo esingapheliyo se-pulmonary (COPD) okanye i-cystic fibrosis, apho ukuveliswa kwe-mucus ngokugqithiseleyo kunye nokukhutshwa okungahambi kakuhle kunokuthintela ukuhamba komoya. Ngokukhuthaza ukukhutshwa kwe-mucus, i-N-Acetylcysteine iphucula ukusebenza kwemiphunga kwaye inciphisa umngcipheko weengxaki zokuphefumula.

Izifundo ezininzi zenzululwazi ziye zaqinisekisa imiphumo emihle ye-N-Acetylcysteine kwimpilo yokuphefumula. Ngokomzekelo, uphando olupapashwe kwi-European Respiratory Journal lubonise ukuba ukuxhaswa kwe-N-Acetylcysteine kuphuculwe ukusebenza kwemiphunga kunye nokunciphisa ukunyuka kokuphefumla kubantu abaneCOPD. Olunye uphando olupapashwe kwi-American Journal of Respiratory and Critical Care Medicine lufumene ukuba i-N-Acetylcysteine yanciphisa ukuphindaphinda kunye nobunzima bokuhlaselwa kwe-asthma kubantwana.

Ngaphandle kweepropathi zayo ze-antioxidant kunye ne-mucolytic, i-N-Acetylcysteine iphinda ibonise iziphumo ezichasayo. Ukuvuvukala luphawu lwezifo zokuphefumula, njengoko kunegalelo ekuthinteleni umoya kunye nokulimala kwezicubu. I-N-Acetylcysteine inceda ukulawula ukukhululwa kweeamolekyu ezivuthayo, ezifana ne-cytokines, kwaye imodareyitha impendulo yomzimba. Ngokunciphisa i-cascade evuthayo, i-N-Acetylcysteine inciphisa iimpawu zokuphefumula kwaye ikhuthaza ukubuyiswa.

Kuyafaneleka ukuba uqaphele ukuba i-N-Acetylcysteine ngokuqhelekileyo ikhuselekile kwaye inyamezeleke kakuhle, kunye nemiphumo emincinci. Nangona kunjalo, njengaso nasiphi na isongezelelo, kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokuba uqalise ukuxhaswa kwe-N-Acetylcysteine, ngakumbi kubantu abaneemeko zonyango eziphantsi okanye abo bathatha amayeza.

Ukuqukumbela, i-N-Acetylcysteine powder yongezelelo olunamandla olubonelela ngeenzuzo ezininzi zempilo yokuphefumula. I-antioxidant, i-mucolytic, kunye ne-anti-inflammatory properties isebenza ngokubambisana ukuxhasa inkqubo yokuphefumula kunye nokunciphisa umonakalo obangelwa uxinzelelo lwe-oxidative kunye nokuvuvukala. Nangona uphando olongezelelweyo lufunekayo ukuze uqonde ngokupheleleyo ubungakanani bonyango lwalo, i-N-Acetylcysteine ibambe isithembiso njengesincedisi sendalo kunye nesisebenzayo ekulawuleni iimeko ezahlukeneyo zokuphefumula.

Ingcaciso yeMveliso

I-N-acetyl cysteine (NAC) ivela kwi-amino acid L-cysteine. Ii-amino acids ziibhloko zokwakha zeeproteni. I-NAC inosetyenziso oluninzi kwaye ilichiza elivunywe yi-FDA.

I-N-acetyl cysteine yi-antioxidant enokuthi idlale indima ekuthinteleni umhlaza. Njengechiza, lisetyenziswa ngababoneleli bezempilo ukunyanga i-acetaminophen (Tylenol) ityhefu. Isebenza ngokubophelela iintlobo ezinetyhefu ze-acetaminophen ezenziwe esibindini.

Abantu ngokuqhelekileyo basebenzisa i-N-acetyl cysteine ukukhohlela kunye nezinye iimeko zemiphunga. Ikwasetyenziselwa umkhuhlane, iliso elomileyo, kunye nezinye iimeko ezininzi, kodwa abukho ubungqina obulungileyo bezenzululwazi bokuxhasa uninzi lwezi zinto zisetyenziswayo. Akukho bungqina bulungileyo bokuxhasa ukusebenzisa i-N-acetyl cysteine ye-COVID-19.

I-N-Acetyl-L-Cysteine i-amino acid, inokuguqulwa emzimbeni we-methionine, i-cystine inokuguqulwa kunye nomnye. I-N-Acetyl-l-cysteine inokusetyenziswa njenge-agent ye-mucilagenic. Ifanelekile ukuthintela ukuphefumla okubangelwa ubuninzi bokuphazamiseka kwe-phlegm. Ukongeza, ingasetyenziselwa ukukhutshwa kwetyhefu ye-acetaminophen.