Indima ye-N-Acetylcysteine ekuxhaseni umsebenzi wemiphunga kubantu abatshayayo

Indima ye-N-Acetylcysteine ekuxhaseni umsebenzi weLung kubatshayi

Igama lemveliso:N-Acetylcysteine

Imbonakalo:Umgubo wekristale omhlophe

Yabelana ku:

Buza I-COA / MADS

Iinkcukacha zeMveliso

Ukuthumela ngenqanawa kunye nokuPakisha

Inkonzo ye-OEM

Ngathi

Iithegi zeMveliso

Ukutshaya ngumkhwa oxhaphakileyo obeka ingozi enkulu kwimpilo, ngakumbi echaphazela ukusebenza kwemiphunga. Iikhemikhali ezinobungozi ezikhoyo kumsi wecuba zinokubangela ukuvuvukala, uxinzelelo lwe-oxidative, kunye nomonakalo kwinkqubo yokuphefumula. Ngenxa yoko, abantu abatshayayo bahlala befumana amandla ancitshisiweyo emiphunga, iimpawu zokuphefumla, kunye nokwanda kokuchaphazeleka kwizifo zokuphefumla. Nangona kunjalo, uphando olutshanje luye lwabonisa ukuba i-N-Acetylcysteine (NAC) capsules okanye ipowder inokudlala indima ebalulekileyo ekuxhaseni umsebenzi wemiphunga kubantu ababhemayo.

I-N-Acetylcysteine yindlela ehlaziyiweyo ye-amino acid cysteine kwaye yenza njenge-precursor ye-glutathione, i-antioxidant enamandla. I-Glutathione iveliswa ngokwemvelo emzimbeni kwaye idlala indima ebalulekileyo ekukhuseleni iiseli kumonakalo we-oxidative. Nangona kunjalo, ukutshaya kuphelisa amanqanaba e-glutathione, okukhokelela ekunyukeni koxinzelelo lwe-oxidative kunye nokuvutha kwimiphunga. Ngokuncedisa nge-N-Acetylcysteine, abatshayayo banokuzalisa amanqanaba e-glutathione kwaye banokunciphisa imiphumo eyingozi yokutshaya kwimpilo yemiphunga.

Enye inzuzo ephambili ye-N-Acetylcysteine kukukwazi ukuphula i-mucus kwi-airways. Ukutshaya kunokubangela ukuveliswa kwe-mucus eninzi, okukhokelela ekuxininiseni kunye nokungasebenzi kakuhle kwemiphunga. I-NAC isebenza ngokunciphisa i-mucus, iyenza kube lula ukuyikhupha. Le propati ye-N-Acetylcysteine inokunceda ababhemayo basuse umoya wabo, banciphise umngcipheko wokusuleleka kwintsholongwane yokuphefumula, kunye nokuphucula ukusebenza kwemiphunga yonke.

Ngaphezu koko, i-N-Acetylcysteine ibonise iipropati ezichasayo. Ukuvutha okubangelwa ukutshaya kwimiphunga kunokubangela umonakalo wezicubu kunye nokuphuhliswa kwezifo ezahlukahlukeneyo zokuphefumula, ezifana nesifo esingapheliyo se-pulmonary (COPD). Uphononongo lubonise ukuba i-NAC inokunceda ekunciphiseni ukuvuvukala kwimiphunga ngokuthintela ukuveliswa kweemolekyuli ze-pro-inflammatory. Ngokunciphisa ukuvuvukala, i-N-Acetylcysteine inokunciphisa ukuqhubela phambili kwezifo zemiphunga ezinxulumene nokutshaya kunye nokunciphisa iimpawu ezinxulumene neemeko zokuphefumula.

Enye inkalo ebalulekileyo ekufuneka iqwalaselwe kukuba kunokwenzeka ukuba i-N-Acetylcysteine ikhusele umonakalo we-oxidative. Ukutshaya kukhokelela ekuveliseni i-radicals yamahhala eyingozi emzimbeni, enokuthi ibangele uxinzelelo lwe-oxidative. Olu xinzelelo lwe-oxidative lonakalisa izakhiwo zeselula kwaye lunegalelo ekuphuhliseni izifo zemiphunga. Ukuxhaswa kwe-NAC kunokunceda ukunciphisa ezi radicals zamahhala kunye nokunciphisa umthwalo woxinzelelo lwe-oxidative kwimiphunga, ngaloo ndlela ixhasa ukusebenza kwemiphunga kunye nokunciphisa umngcipheko weengxaki ezinxulumene nokutshaya.

Kuyafaneleka ukuba uqaphele ukuba uphando olongezelelweyo lusafuneka ukuqonda ngokupheleleyo izibonelelo ze-N-Acetylcysteine ekuxhaseni ukusebenza kwemiphunga kubantu abatshayayo. Nangona ubungqina bangoku buyathembisa, uphando oluninzi luyafuneka ukumisela idosi efanelekileyo, ubude bexesha, kunye nemiphumo yexesha elide yokuxhaswa kwe-NAC. Ukongeza, abantu kufuneka badibane nababoneleli bezempilo ngaphambi kokuba baqale nayiphi na irejimeni entsha yokongeza, ngakumbi ukuba banezimo zonyango esele zikhona okanye bathathe amanye amayeza.

Ekugqibeleni, i-N-Acetylcysteine capsules okanye ipowder inokubonelela ngeenzuzo ezibalulekileyo ekuxhaseni umsebenzi wemiphunga kubantu ababhemayo. Ngokuzalisa amanqanaba e-glutathione, ukuncipha kwe-mucus, ukunciphisa ukuvuvukala, kunye nokukhusela kumonakalo we-oxidative, i-NAC inokunciphisa imiphumo eyingozi yokutshaya kwinkqubo yokuphefumla. Nangona kunjalo, kubalulekile ukuphinda uphonononge lo mbandela ngophando kwaye udibane neengcali zokhathalelo lwempilo ukufumana iingcebiso ezenzelwe wena. Ekugqibeleni, ukuyeka ukutshaya kuhlala kusesona sicwangciso silungileyo sokuphucula ukusebenza kwemiphunga kunye nempilo yonke.

Ingcaciso yeMveliso

I-N-acetyl cysteine (NAC) ivela kwi-amino acid L-cysteine. Ii-amino acids ziibhloko zokwakha zeeproteni. I-NAC inosetyenziso oluninzi kwaye ilichiza elivunywe yi-FDA.

I-N-acetyl cysteine yi-antioxidant enokuthi idlale indima ekuthinteleni umhlaza. Njengechiza, lisetyenziswa ngababoneleli bezempilo ukunyanga i-acetaminophen (Tylenol) ityhefu. Isebenza ngokubophelela iintlobo ezinetyhefu ze-acetaminophen ezenziwe esibindini.

Abantu ngokuqhelekileyo basebenzisa i-N-acetyl cysteine ukukhohlela kunye nezinye iimeko zemiphunga. Ikwasetyenziselwa umkhuhlane, iliso elomileyo, kunye nezinye iimeko ezininzi, kodwa abukho ubungqina obulungileyo bezenzululwazi bokuxhasa uninzi lwezi zinto zisetyenziswayo. Akukho bungqina bulungileyo bokuxhasa ukusebenzisa i-N-acetyl cysteine ye-COVID-19.

I-N-Acetyl-L-Cysteine i-amino acid, inokuguqulwa emzimbeni we-methionine, i-cystine inokuguqulwa kunye nomnye. I-N-Acetyl-l-cysteine inokusetyenziswa njenge-agent ye-mucilagenic. Ifanelekile ukuthintela ukuphefumla okubangelwa ubuninzi bokuphazamiseka kwe-phlegm. Ukongeza, ingasetyenziselwa ukukhutshwa kwetyhefu ye-acetaminophen.