Ukutyhila iNyaniso ngasemva kwe-Kojic Acid Dipalmitate kunye nokusebenza kwayo
Ukutyhila iNyaniso ngasemva kwe-Kojic Acid Dipalmitate kunye nokusebenza kwayo
I-Kojic acid dipalmitate, eyaziwa ngokuba yi-2-Palmitoylmethyl-5-palmitoyl-pyrone, i-fat-soluble derivative ye-kojic acid. Isithako esisebenzayo esiye safumana ukuthandwa kwishishini le-cosmetic ngenxa yokukhanya kwesikhumba kunye ne-melanin-inhibiting properties. Kweli nqaku, siza kuphonononga ukusebenza kwe-kojic acid dipalmitate kwaye sikhanyise ngeenzuzo zayo ezinokuthi zibe kho kulusu.
I-Aogubio, inkampani ekhethekileyo ekuveliseni nasekuhanjisweni kwezinto ezisebenzayo ze-pharmacologically, izinto eziluhlaza, i-extracts yezityalo, kunye ne-nutraceuticals, ibe ngumenzi ohamba phambili we-kojic acid dipalmitate. I-Aogubio izinzile kumashishini amayeza, ukutya, isondlo, kunye ne-cosmetic ngokubonelela ngeemveliso eziphezulu zokusetyenziswa kwabantu. Ngobuchule kunye nolwazi lwabo, i-Aogubio isebenzise ngempumelelo i-kojic acid dipalmitate kwimveliso yezithambiso, iyenza ibe ngumthombo othembekileyo wesi sithako esinamandla.
I-asidi ye-Kojic, i-precursor ye-kojic acid dipalmitate, i-agent ehlanjululwayo eveliswa ziifungi ezininzi ezifana ne-Aspergillus oryzae, i-Aspergillus parasiticus, kunye ne-Aspergillus flavus. Ikwafumaneka nasekutyeni okubilisiweyo okufana nesosi yesoya, intlama yeembotyi zesoya, kunye newayini. AmaJapan asebenzisa i-kojic acid kangangeenkulungwane kwimveliso yewayini yaseJapan yerayisi, eyaziwa ngokuba yi "jiu koji." IJapan iye yahlala ingumvelisi ophambili we-kojic acid kwihlabathi liphela ukusukela ngeminyaka yoo-1970.
Ububodwa be-kojic acid dipalmitate buhlala ekuzinzeni nasekusebenzeni kwayo xa kuthelekiswa ne-kojic acid yendabuko. I-asidi ye-Kojic yaziwa ngokungazinzi ekukhanyeni, ubushushu, kunye nee-ion zesinyithi, ezinokubeka esichengeni ukusebenza kwayo. Nangona kunjalo, ngokungeniswa kwe-kojic acid dipalmitate, ezi ntsilelo zoyiswa. I-esterification yeqela elisebenzayo le-hydroxyl kwisakhiwo se-molecular ye-kojic acid dipalmitate iyayikhusela ekwenzeni iibhondi ze-hydrogen kunye nezinye izithako zokuthambisa. Oku kuqinisekisa ukuba ukusebenza kwezinye izongezo akuchaphazeleki, ukuvumela intsebenziswano engcono kunye nezinye izinto eziluhlaza kwizinto zokuthambisa.
Enye yeenzuzo eziphambili ze-kojic acid dipalmitate kukukwazi ukuthintela ukubunjwa kwe-melanin. I-Melanin inoxanduva lokumnyama kwesikhumba, kwaye ukuveliswa kwayo ngokugqithiseleyo kunokukhokelela kwi-hyperpigmentation kunye nethoni engalinganiyo yesikhumba. Ngokuthintela i-tyrosinase, i-enzyme ebandakanyekayo ekuveliseni i-melanin, i-kojic acid dipalmitate inceda ukukhanyisa ulusu kunye nokunciphisa ukubonakala kwamabala amnyama kunye namabala. Ukuqulunqwa okuyingqayizivele kwe-kojic acid dipalmitate iqinisekisa ukuba umsebenzi wayo ogqwesileyo ugcinwa, unika iziphumo ezisebenzayo zokukhanya kwesikhumba.
Ngaphaya koko, i-kojic acid dipalmitate ibonelela ngeempawu zokuthambisa, iyenza ibe yeyona nto ifanelekileyo kwizithambiso. Ukuhambelana kwayo nezinye izinto eziluhlaza zokuthambisa ivumela ukuba isebenze ngokubambisana, ihambisa i-hydration eluswini ngaphandle kokubeka esichengeni ukusebenza kwezinye izongezo. Oku kwenza i-kojic acid idipalmitate isithako esiguquguqukayo esingakhanyisi nje ulusu kuphela kodwa silondle kwaye silufake emanzini, ukukhuthaza ibala eliphilileyo neliqaqambileyo.
Ukuqukumbela, i-kojic acid dipalmitate iyisithako esinamandla kwi-cosmetic industry, eyaziwa ngokuba yi-skin-lighting and melanin-inhibiting properties. I-Aogubio, inkampani ehloniphekileyo ekhethekileyo ekuveliseni nasekuhanjisweni kwezinto ezisebenzayo kunye nezinto eziphathekayo, ifake ngempumelelo i-kojic acid dipalmitate kwiimveliso zabo zokuthambisa. Ngozinzo, ukusebenza kakuhle, kunye neempawu zokuthambisa, i-kojic acid dipalmitate ibonelela ngesisombululo esihle kwabo bafuna ukuphucula inkangeleko yolusu lwabo kwaye bafezekise ngakumbi ibala.
IiNkcazo zeeMveliso
I-Kojic acid dipalmitate iguqulwe i-kojic acid derivative, engapheleli nje ekoyiseni ukungazinzi kokukhanya, ubushushu kunye ne-ion yensimbi, kodwa igcina umsebenzi we-tyrosinase inhibitory kwaye inqanda ukubunjwa kwe-melanin. I-Kojic dipalmitate inepropati ezinzileyo yekhemikhali. Ayiyi kujika ibe tyheli kwi-oxidation, i-ion yensimbi, ukukhanyisa kunye nokufudumeza.
Umsebenzi
- i-kojic acid dipalmitate luhlobo oluthile lwe-inhibitor ye-melanin. Inokuthintela umsebenzi we-tyrosinase ngokudibanisa i-ion yobhedu kwiiseli emva kokuba ingene kwiiseli zesikhumba. I-asidi ye-Kojic kunye ne-derivative yayo inempembelelo engcono yokuthintela kwi-tyrosinase kunayo nayiphi na enye i-agent emhlophe yolusu.
- i-kojic acid dipalmitate inokuphelisa i-radical yasimahla, yomeleza umsebenzi weseli kwaye igcine ukutya kusitsha.
UPHICOTHO OLUYISISEKO
| UHLALUTYO | INGCACISO | IZIPHUMO |
| Imbonakalo | Umgubo oMhlophe | Iyahambelana |
| Ivumba | Uphawu | Iyahambelana |
| Wangcamla | Uphawu | Iyahambelana |
| Isivavanyi | 99% | Iyahambelana |
| Uhlalutyo lweSieve | I-100% iphumelele i-80 mesh | Iyahambelana |
| Ilahleko ekomisweni | 5% Ubuninzi. | 1.02% |
| Uthuthu lweSulfate | 5% Ubuninzi. | 1.3% |
| Ukukhupha i-Solvent | I-Ethanol kunye naManzi | Iyahambelana |
| Intsimbi enzima | 5ppm max | Iyahambelana |
| Njengoko | 2ppm max | Iyahambelana |
| Izinyibilikisi ezishiyekileyo | 0.05% Ubukhulu. | Ibi |
| IMicrobiology | ||
| Ubalo lwePleti lulonke | 1000/g Ubuninzi | Iyahambelana |
| Igwele kunye noMngundo | 100/g Ubuninzi | Iyahambelana |
| E.Coli | Ibi | Iyahambelana |
| Salmonella | Ibi | Iyahambelana |
Usetyenziso
Iitoni zokunyamekela umzimba/ubuso, amalungiselelo okulwa nokuguga, ukukhuselwa kwelanga, emva kokutshiswa lilanga kunye nokuzitshisa, ukwenza mhlophe ulusu/ukukhanya, unyango lweentlobo ngeentlobo zeemeko zolusu lwe-hyperpigmentation okanye iziphazamiso, umz. i-solar lentigenes, i-melasma, i-chloasma, ama-scars, ama-freckles, ubudala bebala kunye neminye imimandla yesikhumba hyperpigmented
