Xa kuziwa kwimpilo kunye nokuba sempilweni, ukufumana izongezo ezifanelekileyo kunokwenza umahluko wehlabathi. UKeira uza kukuxelela malunga ne-resveratrol kwesi sithuba namhlanje. I-Resveratrol idume kwihlabathi ngenxa ye-Paradox yesiFrentshi eyaxoxwa kwiminyaka yoo-1990, xa kwakukholelwa ukuba isizathu sokuba abantu baseFransi abatya ukutya okunamafutha amaninzi bangabi sengozini yesifo senhliziyo kungenxa yokuba i-resveratrol iqulethwe kwiwayini ebomvu abahlala beyisela. .
Ukususela ngoko, i-resveratrol iye yaqhubeka ifunyanwa ngenxa yeenzuzo zayo zempilo, kuquka i-antioxidant, i-anti-inflammatory, anti-cancer, kunye ne-cardiovascular protective effects.
Yintoni i-resveratrol?
Resveratrol, i-polyphenol non-flavonoid i-organic compound, i-antitoxin eveliswa zizityalo ezininzi xa ivuselelwe, kunye ne-chemical formula C14H12O3. Ngo-1940, umphengululi waseJapan uMichioTakaoka waqala wakhetha i-resveratrol esuka kwi-albhamu yeVeratrum kusapho lwenyibiba, kwaye kamva wayifumana kwiPolygonum cuspidatum kusapho lwepolygonum ngo-1963. incindi yomdiliya. Ifunxwa lula ngomlomo kwaye ikhutshwe kumchamo kunye nesitulo emva kwemetabolism. Uvavanyo lwe-in vitro kunye nezilwanyana lubonise ukuba i-resveratrol ine-antioxidant, i-anti-inflammatory, i-anticancer kunye ne-cardiovascular protective effects.
Resveratrolisasazwa ngokubanzi kwizityalo, kwaye ukususela ngo-2021, ifunyenwe kwizityalo ezingaphezu kwe-70 ezivela kwiintsapho ze-21, Ngokukodwa, i-itis efunyenwe kwi-Vitis, i-Ampelopsis, i-Polygonum, i-Arachis, i-Cassia, i-Sophora, i-Veratrum, i-Veratrum kunye ne-Eucalyptus. Izityalo eziqhelekileyo eziqulethe i-resveratrol ziquka iidiliya, i-knotweed, i-peanuts, i-cassia, njl njl. Indlela yokudibanisa imichiza ye-resveratrol enenkqubo elula nevuthiweyo, isivuno esiphezulu semveliso kunye neendleko eziphantsi zemveliso isetyenziselwe ukulungiswa kobunzima boshishino, ukwenzela ukuba ukufunyanwa kwe-resveratrol akukho. ixesha elide kuxhomekeke ekutsalweni kunye nokwahlulwa kwizityalo. Inkqubo ye-synthesis ye-resveratrol ikakhulu isebenzisa i-Wittig reaction ukuze iqonde ukudityaniswa kwamakhonkco amabini e-benzene, kwaye isivuno sinokufikelela ngaphezu kwe-50%.
Ziziphi iziphumo ze-resveratrol?
- Ukuchasa ukuguga
Kwiminyaka yakutshanje, kuye kwafunyaniswa ukuba uninzi lwe-polyphenols lune-anti-oxidation ebalulekileyo kunye nemiphumo echasene ne-radical yamahhala.
Njenge-antioxidant yendalo, i-resveratrol inamandla okuziphelisa kunye ne-anti-lipid peroxidation, kwaye ithelekiswa ne-antioxidants yendabuko efana ne-vitamin C, i-butylhydroxytoluene, i-tocopherol, i-resveratrol ine-antioxidant effect engcono.
Resveratrolyenza i-antioxidant isiphumo ngokuyinhloko ngokukhupha okanye ukuvimbela i-radicals yamahhala, inqanda i-lipid peroxidation, ilawula umsebenzi we-enzymes ezinxulumene ne-antioxidation kunye nezinye iindlela.
I-Resveratrol ixhathisa ukuguga okubangelwa yi-lipid peroxidation ebangelwa yi-radicals yamahhala kunye ne-metabolites yazo. Ngelo xesha, i-resveratrol isusa i-radicals yamahhala, iyanciphisa umxholo we-H₂O₂ elukhumbeni, iphucula umsebenzi we-ATPase, kwaye ngoko inomphumo wokulibazisa ukuguga kwesikhumba.
- Lawula iswekile yegazi
Isifo seswekile sesona sigulo sixhaphakileyo esingapheliyo, kodwa sesona sithintelwe ngokulula, kodwa ngenxa yoko kudla ngokuvumela abantu ukuba bathathe kancinci, ingxaki yesifo seswekile, yi-arteriosclerosis, ukongeza ukunyusa kakhulu amathuba okuba i-myocardial infarction, stroke, ukuba ichaphazela i-microvessels yezintso, iya kubangela ukusilela kwezintso, ngoko ke indlela yokulawula iswekile yegazi ibalulekile ebomini.
Kwisifundo esincinci, i-resveratrol (i-150 mg imihla ngemihla ngeentsuku ze-30, i-DSM proprietary component resVida) iphucule amanqanaba eshukela egazi (ngo-4.2%) kunye namanqanaba e-insulin (nge-13.7%) kubantu abakhulu kakhulu.
- I-anti-tumor, i-anti-cancer
I-Resveratrol inempembelelo ebalulekileyo yokuthintela kwi-hepatocellular carcinoma, umhlaza wamabele, umhlaza wekoloni, umhlaza wesisu, i-leukemia kunye nezinye iiseli zethumba. Abanye abaphengululi baye baqinisekisa ukuba i-resveratrol inempembelelo ecacileyo yokuthintela kwiiseli ze-melanoma ngendlela ye-MTT kunye ne-cytometry yokuhamba.
Kuye kwaxelwa ukuba i-resveratrol inokuphucula unyango lwemitha yomhlaza, idlale "i-1+1> 2" isiphumo, kwaye ithintele ngokufanelekileyo indima yeeseli zomhlaza. Kodwa ukuza kuthi ga ngoku, ngenxa yobunzima be-anti-tumor mechanism ye-resveratrol, abaphandi abakafikeleli kwisivumelwano malunga nendlela yokusebenza kwayo.
- Eminye imisebenzi
I-Resveratrol nayo ine-antibacterial, i-antioxidant, i-immunomodulatory, i-antiasthmatic kunye neminye imisebenzi ye-biological. I-Resveratrol ifunwa kakhulu ngenxa yemisebenzi yayo eyahlukeneyo yebhayoloji.
Indlela yokukhupha i-resveratrol?
- Indlela yokutsalwa kwezityalo zendalo
I-Resveratrol yakhutshwa kwaye yahlanjululwa kumdiliya, i-knotweed kunye ne-peanut. Itekhnoloji ye-crude extraction ikakhulu ibandakanya indlela ye-organic solvent extraction, indlela yokukhutshwa kwe-alkali kunye ne-enzyme extraction method, i-microwave incedise indlela yokukhupha, i-CO2 i-supercritical extraction, i-ultrasonic incedise i-extract extraction kunye nezinye iindlela ezintsha nazo zisetyenziswa. Injongo ephambili yokuhlanjululwa kukwahlula i-resveratrol cis, i-trans isomer kunye ne-resveratrol i-Xib kwi-resveratrol eluhlaza ekhutshweyo ukuze ufumane i-trans-resveratrol. Iindlela zokucoca eziqhele ukusetyenziswa yichromatography, isilica gel ikholamu chromatography, umaleko obhityileyo chromatography, ukusebenza okuphezulu chromatography engamanzi njalo njalo.
- Indlela yokudibanisa
Ngenxa yomxholo ophantsi we-resveratrol kwizityalo kunye neendleko eziphezulu zokukhutshwa, ukusetyenziswa kweekhemikhali, i-biological kunye neendlela zobunjineli bezofuzo zokufumana i-resveratrol ibe yindlela efunekayo kwinkqubo yophuhliso. I-Perkin reaction, i-Hech reaction kunye ne-Witting-Hormer yokusabela ziindlela zekhemikhali ezivuthiweyo ze-synthesis ye-resveratrol, kunye nesivuno se-55.2%, i-70% kunye ne-35.7%, ngokulandelanayo. Ukusebenzisa iteknoloji yobunjineli bofuzo ukulawula okanye ukuphucula indlela ye-biosynthesis ye-resveratrol ukufumana imigca yezityalo eziphezulu; Isivuno se-resveratrol sanyuswa ngamaxesha e-1.5 ~ 3.0 nge-mutagenesis kunye nezinye iindlela.
I-Aogubio yinkampani ejongene nemveliso kunye nokusasazwa kwezinto ezisebenza nge-pharmacologically, izinto eziluhlaza kunye nezityalo ezicatshulwayo, kubandakanywa i-nutraceuticals yokuvelisa izongezo zabantu. Sigxininise kumayeza kunye neemveliso zamachiza, ukutya, i-nutraceutical kunye ne-cosmetic industries, kwaye sizibophelele ekuboneleleni abathengi abanomgangatho ophezulu kunye nezongezo ezisebenzayo.I-Resveratrol yenye yezithako esizinikezelayo kwizityalo zezityalo.
UKUQINISEKISA UMGANGATHO:
Indawo yethu ixhotyiswe ngebhubhoratri esebenzisa i-chromatography yerhasi ye-state-of-the-art ukuvavanya ngokungqongqo ukucoceka kunye namandla ezinto zethu eziluhlaza; ukuqinisekisa ukuba abathengi bethu bafumana iimveliso ezikumgangatho ophezulu ngamaxesha onke.
INKONZO EYENZELWE:
Ukugcina injongo yethu yokuzalisekisa uMgaqo-nkqubo weSiqinisekiso soKwaneliseka, iqela lethu elizinikeleyo lihlala lilungele ukubonelela ngamnye kubathengi bethu ngenkonzo ekhokelayo kwishishini kuyo yonke inkalo yomyalelo.
Ukuba ufuna ukwazi okanye ukuthenga umgangatho ophezulu we-resveratrol, nceda uqhagamshelane no-kayla.
Qhagamshelana: Keira Zhang
I-imeyile: sales06@aogubio.com
Umnxeba: +86 18066856327
Ixesha lokuposa: Jan-08-2024
