Yintoni iSpermidine & nicotinamide mononucleotide (NMN)?
I-Spermidine yi-polyamine, oku kuthetha ukuba inamaqela amabini okanye ngaphezulu aphambili amino. Yenzeka ngokwemvelo kwaye idibana ngokubanzi kwi-ribosomes kunye nezicubu eziphilayo. Idlala indima ebalulekileyo ekusebenzeni kweeseli kunye nokuphila.
I-Spermidine yaqala ukufunyanwa ngo-1678 ngusosayensi waseDatshi uAnton Van Leeuwenhoek kwisampulu yesidoda somntu. Kungekudala emva koko, i-spermidine yafunyanwa kwisidoda somntu. Emzimbeni, i-spermidine idalwe kwi-purescine yangaphambili. Yi-precursor yenye i-polyamine ebizwa ngokuba yi-spermine, ekwabalulekile kumsebenzi weselula.
I-Spermidine kunye ne-purescine ziyaziwa ngokuvuselela i-autophagy. Isixokelelwano esaphula inkunkuma engaphakathi kweeseli kwaye iphinde isebenzise iinxalenye zeselula. Yindlela ebalulekileyo yokulawula umgangatho we-mitochondria, izindlu zamandla kwiiseli zethu. I-Autophagy ivumela i-mitochondria eyonakeleyo okanye enesiphene ukuba yaphulwe kwaye ilahlwe. Ukulahlwa kwe-mitochondria kulawulwa ngokungqongqo ngakumbi kunokuba bekukholelwa ngaphambili.
Iipolyamines zinokuzibophelela kwiindidi ezininzi ezahlukeneyo zeemolekyuli zizenza zibe luncedo kakhulu. Baxhasa iinkqubo, kubandakanya ukukhula kweeseli, ukuzinza kweDNA, ukwanda kweeseli, kunye ne-apoptosis [2]. Kwakhona kubonakala ukuba iipolyamines zisebenza ngendlela efanayo kwizinto zokukhula ngexesha lokuhlukana kweeseli. Yingakho i-purescine kunye ne-spermidine zibalulekile ekukhuleni kwezicubu ezinempilo kunye nokusebenza.
I-NMN luhlobo lwemolekyuli ebizwa ngokuba yi-nucleotide. IiNucleotides zidlala iindima ezininzi emzimbeni wakho, kuquka njengeebhloko zokwakha zeDNA.
Ngaphakathi kweeseli zakho, i-NMN iguqulelwa kwenye imolekyuli eyaziwa ngokuba yi-nicotinamide adenine dinucleotide (NAD). Umzimba wakho udinga i-NAD kwimisebenzi eyahlukeneyo ebandakanyekayo kwimetabolism kunye nokuveliswa kwamandla.
Unokucinga nge-NMN njengento ekrwada kunye ne-NAD njengoguqulelo olusulungekileyo onokulusebenzisa ngokwenene umzimba wakho.
Isixa se-NAD esinokwenziwa ngumzimba wakho sixhomekeke kubungakanani be-NMN ekhoyo emzimbeni wakho.
Kukuphi ukutya okukwi-spermidine &nicotinamide mononucleotide (NMN)?
Kukho imithombo emininzi yokutya ye-spermidine equka i-grapefruit, iimveliso zesoya, i-legumes, i-corn, i-corn, i-chickpeas, i-peas, i-pepper eluhlaza, i-broccoli, i-orenji, iti eluhlaza, i-rice bran, kunye ne-pepper eluhlaza.
Inokufumaneka nakwi shitake mushrooms, amaranth grain, wheat germ, cauliflower, broccoli, kunye neendidi zetshizi ezivuthiweyo, kunye ne durian.
Kuyafaneleka ukuba uqaphele ukuba ukutya okuninzi kweMeditera kuqulethe ukutya okutyebileyo kwe-spermidine. Oku kunokucacisa ubuncinci beziganeko "zeendawo eziluhlaza" kwaye kutheni abantu bahlala ixesha elide kunezinye iindawo.
I-NMN ngokwayo yinto equlethwe emzimbeni womntu, ekhoyo kubisi lwebele kunye nokutya, njenge-edmpoa, i-broccoli, ikhukhamba, iklabishi, i-avocados, i-tomato, njl., kodwa umxholo uncinci kakhulu (0.25-1.88 mg nge-100 nganye). iigram). Inyama yenkomo ekrwada kunye ne-shrimp nayo iqulethe ixabiso elincinci kakhulu (0.06-0.42 mg nge-100 g) ye-NMN.
Izinto eziluncedo kwi-spermidine &nicotinamide mononucleotide (NMN):
I-Spermidine ibophelela kwi-NMN, ikhulisa ngokufanelekileyo izibonelelo zabo
I-Spermidine kunye ne-autophagy:I-Spermidine ikwadlala indima ephambili kwiinkqubo ezininzi ezibalulekileyo zebhayoloji，Ikhono le-spermidine lokuqalisa i-autophagy kucingelwa ukuba yeyona ndlela iphambili ebonakala ngathi icothisa ukuguga kunye nokuxhasa ubomi obude.
Iimpawu zeSpermidine ezichasayo:Yamkelwa ngokubanzi into yokuba ngoxa ukudumba kunendima eluncedo ekunyangeni inxeba nasekugxotheni iintsholongwane ezihlaselayo, ukudumba okuzingileyo okunxulunyaniswa nokwaluphala, okudla ngokubizwa ngokuba kukudumba, kuyingozi. Ukudumba okungapheliyo kuthintela ukuvuselelwa kwezicubu ezisempilweni, kubangela ukuba iiseli zomzimba zingasebenzi kakuhle, kwaye zinokukhawulezisa isantya apho iiseli ezisempilweni ziye zibe senescent. I-Spermidine ibonakala inciphisa ukudumba okungapheliyo kwaye inokunciphisa enye indlela apho iiseli kunye nezicubu ziguga.
I-Spermidine kwaye inokulibazisa ukuguga:Kubomi obude, ulawulo lwe-spermidine lubonakaliswe ukwandisa ubomi kwinani lezifundo zezilwanyana kunye nokuthintela i-fibrosis yesibindi kunye ne-hepatocellular carcinoma. Oku kubonakala kunjalo nangokutya okutyebileyo kwi-polyamines. Kukho nobunye ubungqina obubonisa ukuba kuphucula ukuchasana noxinzelelo kunye nokuba ukuhla kwe-spermidine okunxulumene neminyaka kuxhasa ukuqala kwezifo ezinxulumene neminyaka.
I-Spermidine inokunciphisa ukuhla kwengqondo:Uphando olupapashwe ngo-2021 kwijenali yeeNgxelo zeCell lubonelela ngengxelo eneenkcukacha ye-dietary spermidine ephucula ukuqonda kunye nomsebenzi we-mitochondrial kwiimpukane kunye neempuku, kunye nedatha yabantu abanokubakho ukuyigqiba. Nangona olu phononongo lwalunomdla, lwalunemida ethile, kwaye idatha eyongezelelweyo ye-dose-response iyadingeka ngaphambi kokuba isigqibo esiqinileyo singenziwa malunga neenzuzo ekuqondeni komntu.
Ukuphucula ukusebenza kwengqondo:I-NMN ibonakaliswe ukuphucula ukuqonda kwiigundane ezine-Alzheimer kunye nokunciphisa iiplagi zengqondo kunye ne-neurodegenration kwiigundane ze-Alzheimer. Ngelixa i-Alzheimer's sisifo sokugqibela, abantu abadala abaninzi nabo banengxaki yokuphazamiseka kwengqondo - ukungakwazi ukufunda, ukukhumbula kunye nokucinga kakuhle. Ezi ziphazamiso ezinxulumene neminyaka yobudala zithintelwe yi-NMN kwiimpuku. Ukuphazamiseka kwengqondo ngamanye amaxesha kudibaniswa nokudakumba, okuye kwaboniswa ukuba kuncitshiswe yi-NMN kwiimpuku.
Ngenxa yokuba imithambo yegazi yethu ingasebenzi kakuhle njengoko sikhula, ukuhamba kwegazi ukuya kwingqondo yethu kuphazamiseka, okukhokelela kukuphazamiseka kwengqondo. I-NMN ibonakaliswe ukwandisa ukuhamba kwegazi kwingqondo kunye nokuphucula umsebenzi wokuqonda kwiigundane. Xa imithambo yegazi ebuchotsheni bethu ivalekile, sinokuba ne-stroke, apho izicubu zethu zengqondo zonakale. I-NMN ibonakaliswe kungekuphela nje ukulibazisa ukuqala kwe-stroke, kodwa kunye nokuthintela umonakalo we-stroke, kunye nokuphucula ukuqonda kunye nempilo ye-mitochondrial emva kokushaywa kwe-stroke kwiigundane.
Ukuphucula ukusebenza kwezihlunu:Sithembele kwimisipha yethu yamathambo ukuhamba, ukuzinza, kunye namandla. Njengoko sikhula, izihlunu zethu zilahlekelwa ukukwazi ukuvuselela nokukhula, okukhokelela ekunciphiseni okunxulumene neminyaka kumandla omzimba kunye nobukhulu obubizwa ngokuba yi-sarcopenia. Kunye nobuthathaka bemisipha, siphinda sidinwe ngakumbi kwaye sibe nokunyamezela komzimba okuncinci. I-NMN ibonakala iguqula le miqathango, njengoko omnye wabathuthi bayo ubonakaliswe ukwandisa amandla kunye nokunyamezela ngokomzimba kwiigundane.
Ikhuthaza Intliziyo Esempilweni: I-NMN ibonakaliswe ukukhusela ukusilela kwentliziyo kwiimpuku. Izicubu zentliziyo yethu zixabisekile, njengoko zingaziwa ukuba ziphinda zikhule. Endaweni yoko, izicubu ezonakeleyo zibonakala kwi-scarring (fibrosis), ekhokelela kukungasebenzi kakuhle kwentliziyo. I-NMN ibuyisela umsebenzi wentliziyo yempuku ngokunciphisa amanxeba. Ukubetha rhoqo kwaye rhoqo, intliziyo ifuna umthamo omkhulu wamandla. Kule nto, idinga i-mitochondria enempilo. I-NMN iphucula imetabolism yentliziyo kwaye ikhusela ukungaphumeleli kwentliziyo, ngokuyinxenye ngokuvuselela i-mitochondria.
Ikhusela ukutyeba kakhulu kunye nesifo seswekile:Ukutyeba kunxulunyaniswa noluhlu olubanzi lokungaphumeleli kwe-metabolic, kubandakanywa nokumelana ne-insulin-xa iiseli zingenako ukusebenzisa i-glucose ngenxa yokuphazamiseka kokubonakaliswa kwe-insulin-enokukhokelela kwisifo seswekile. I-Mitochondria yindawo yokugqibela yeselula yokuya kukutya esikutyayo ukuze kuguqulwe amandla, kubenze babaluleke kakhulu kwimetabolism kunye nezifo ezinxulumene nazo. I-NMN ibonakaliswe ukuphinda kabini isixa se-mitochondria kwizibindi zeempuku ezityebileyo, ezinokukhusela ukutyeba. Ukuvuselela ukuwohloka kwamafutha nge-NMN kunokunceda abantu abatyebe kakhulu balahlekelwe ngamafutha.
Uncedo lwe-NMN ngokuguga: Amanqanaba e-NMN kunye ne-NAD ngokwendalo aye ehla ngokukhula, ngoko ke abaphandi abaninzi baye bacebisa ukuba ukuthatha izongezo ze-NMN kunokunceda kwiinkxalabo zempilo ezinxulumene nobudala.
Uphononongo kumadoda angama-10 aseJapan afumanisa ukuba ukuthatha i-NMN (i-100, i-250, okanye i-500 mg) inyuse amanqanaba e-NMN ngeproducts egazini, kubandakanywa ne-NAD.Ukunganyangeki kwe-insulin kunokukhula nge-ageTrusted Source kwaye sesinye sezizathu zokuba isifo sikashukela sixhaphake kakhulu kubantu abadala. abadala. Ukuthatha izongezelelo ze-NMN kuye kwaboniswa ukunciphisa ukozela kunye nokuphucula ukuphendula kwemisipha kubantu abadala, okunokuphucula impilo yomzimba kunye nengqondo kunye nobudala.
Umthamo
Ngenxa yedatha enyiniweyo ekhoyo ekuthatheni izongezo ze-NMN, kunzima ukumisela idosi efanelekileyo. Uphononongo lufumene inzuzo yezempilo kunye needosi eziphantsi njenge-250 mg ye-NMN ngosuku, kunye ne-Spermidine dosage ye-10 - 20 mg.
Ukuba unomdla, nceda uzive ukhululekile ukuqhagamshelana ne-XI'AN AOGU BIOTECH !
Ixesha lokuposa: Dec-29-2022
