Deoxyarbutin, njenge-Tyrosinase inhibitor ekhuphisanayo, inokulawula ukuveliswa kwe-melanin, inqobe i-pigmentation, i-fade yesikhumba amabala amnyama, kwaye ibe nefuthe elikhawulezayo nelihlala lihlala limhlophe. Isiphumo esithintelayo se-deoxyaarbutin kwiTyrosinase ngokucacileyo siphezulu kunezinye ii-activators ezimhlophe, kwaye umphumo wokukhanya kunye nokukhanya unokufezekiswa ngokusetyenziswa okuncinci. I-Deoxyarbutin nayo ineempembelelo ezinamandla ze-antioxidant
- Igama lesiTshayina elithi Deoxyarbutin
- Igama langaphandle iDeoxyarbutin
- Isiteketiso p - (tetrahydro-2H-pyran-2-oxy) phenol
- Ifomula yekhemikhali C11H14O3
- Ubunzima bemolekyuli 194.23
- Inombolo yokungena yeCAS 53936-56-4
- Isibizo sesiNgesi 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Ubunyulu ≥ 98%
Deoxyarbutinnjengesizukulwana esitsha sokuqaqamba kwezithambiso kunye nokwenza mhlophe iarhente esebenzayo, isetyenziswa ikakhulu kwizinto zokuthambisa eziphucukileyo.
Uvavanyo
Ukumodareyithwa kwe-melanogenesis kwi-melanocytes kunokufezekiswa kusetyenziswa iikhemikhali ezabelana nge-homologies yesakhiwo kunye ne-substrate tyrosine kwaye ngenxa yoko ngokhuphisanayo inqanda umsebenzi we-catalytic we-tyrosinase. Senze i-tyrosinase inhibitor entsha, i-deoxyArbutin (dA), esekwe kwesi siseko. I-DeoxyArbutin ibonisa inhibition esebenzayo ye-mushroom tyrosinase in vitro ene-Ki engaphantsi ka-10 ngaphantsi kwe-hydroquinone (HQ) kunye ne-350 engaphantsi kwe-arbutin. Kwimodeli yehagu yehagu engenaboya, enemibala, i-dA ibonise ukhanyiso olukhawulezayo noluzinzileyo olukwaziyo ukubuyiselwa umva ngokupheleleyo kwiiveki ezisi-8 emva kokunqunyanyiswa kwesicelo esisentloko.
Ngokwahlukileyo koko, i-HQ iye yavelisa isiphumo esifutshane kodwa esingazinzanga sokukhanyisa ulusu ngelixa i-kojic acid kunye ne-arbutin zingabonakalisi siphumo sokukhanya kolusu. Iziphumo ezivela kwiqela lovavanyo lokhuseleko zixhase ukusekwa ngokubanzi kwe-DA njengemolekyuli esebenzayo. Kulingo lwezonyango lomntu, unyango olusentloko lwe-dA kwiiveki ezili-12 lukhokelele ekuncipheni okubalulekileyo okanye okuncinci ekukhanyeni kolusu lulonke kunye nokuphuculwa kwee-solar lentigines kubemi besikhumba esikhanyayo okanye abantu bolusu olumnyama, ngokulandelelanayo. Ezi datha zibonisa ukuba i-dA inomsebenzi onokuthi uthintele i-tyrosinase enokuthi ibangele ukukhanya kwesikhumba kwaye ingasetyenziselwa ukuvuselela izilonda ze-hyperpigmentary.
Intshayelelo
I-Melasma (i-chloasma) sisifo se-pigmentary solusu esixhaphakileyo esibonakaliswa kukukhanya okungaqhelekanga ukuya kumabala amnyama ebusweni, adla ngokubangela umthwalo obalulekileyo ngokwasengqondweni nangokwengqondo kubantu abachaphazelekayo. Nangona kunjalo, iziganeko ezikhuthazayo ze-pathogenesis ye-melasma aziqondi kakuhle. I-Melasma ixhaphake kakhulu kubantu abaneentlobo ze-Fitzpatrick zesikhumba IV nge-VI kunabo banolusu olulungileyo (iintlobo ze-I ukuya ku-III). I-Melasma ikwabonwa ukuba ixhaphake kakhulu phakathi kwabasetyhini kunamadoda kwaye ixhaphake kakhulu phakathi kwama-Asiya, iLatinos kunye nama-Afrika-aseMelika kunaphakathi kwamaCaucasus. Kuqikelelwa ukuba i-50% ukuya kwi-70% yabasetyhini abakhulelweyo e-US bahlakulela i-melasma [3].
Kuye kwafunyaniswa ukuba i-hyperactive melanocytes kwi-melasma skin ivelisa i-melanin pigment eninzi nge-tyrosine catabolism pathway. I-Tyrosinase (EC 1.14.18.1), i-glycoprotein enobhedu, yi-enzyme yokunciphisa izinga elibalulekileyo kule ndlela. Ukwenziwa kwe-melanin kwenzeka kwii-organelles ezikhethekileyo ezibizwa ngokuba zii-melanosomes kwaye ke ii-melanosomes ezi-melanized zigqithiselwa ukusuka kwi-melanocytes ukuya kwi-keratinocytes engabamelwane, ngaloo ndlela kumiselwa umbala wolusu obambekayo kunye osebenzayo. Uninzi lweearhente ezikhanyisa ulusu zijolise ekulawuleni i-melanin synthesis ngokucinezelwa komsebenzi we-tyrosinase. Kwiminyaka engama-50 edlulileyo, i-hydroquinone (1, 4-benzenediol, HQ) ibisetyenziswa ngokubanzi njengomgangatho wegolide weprototypical tyrosinase inhibitors ekunyangeni i-melasma. Nangona kunjalo, ingqwalasela enkulu yakutshanje ihlawulwe kwingozi yempilo enokubakho yokuvezwa kwexesha elide kwi-HQ, efana ne-exogenous ochronosis, i-leukoderma (i-vitiligo yomsebenzi), kunye ne-carcinogenesis. umsebenzi, ukunika amandla okuba mhlophe kwesikhumba. Ngeli xesha, ezi khompawundi ze-monophenol nazo zinika ukuphakama, ngokusebenzisa i-enzymatic oxidation yi-tyrosinase, kwi-radicals eninzi yamahhala eyenza i-lipid peroxidation kunye nomonakalo obangelwayo we-melanosomal membrane. -pyran-2-yl) oxy] phenol, D-Arb), iglucoside derivative of HQ, ikhuselekile kwaye incinci i-cytotoxic xa ithelekiswa nonina wayo i-hydroquinone. Uphononongo lwangoku lwenzelwe ukuphanda ubutyhefu kunye nokusebenza kakuhle kwe-D-Arb kwinqanaba elisezantsi leselula (ngokuthe ngqo kwi-melanosomes) kunye ne-pigmentation yesikhumba kusetyenziswa imodeli ye-vivo kunye ne-in vitro, ivavanya ngakumbi i-biosafety ye-D-Arb ngokuthelekisana ne-HQ. ukusetyenziswa ukhanyisa ulusu.
Deoxyarbutin, njengesizukulwana esitsha sokuqaqamba kwezithambiso kunye ne-ejenti esebenzayo esebenzayo, isetyenziswa ikakhulu kwizinto zokuthambisa eziphucukileyo.
I-D-Arbutin yenye yezinto eziphuma kwi-Arbutin, ebizwa ngokuba yi-D-nenenebb arbutin, enokuthintela ngokufanelekileyo isenzo se-tyrosinase kwizicubu zesikhumba. Ngokutsho kophando, isiphumo salo siphindwe ka-10 kune-hydroquinone kunye namaxesha angama-350 e-Arbutin ngokubanzi. Kuvavanyo lwesikhumba sesilwanyana, le D-Arbutin inokulusukisa ngokukhawuleza nangempumelelo, kwaye emva kokuyeka ukusetyenziswa, isiphumo sisenokugcinwa phantse iiveki ezisi-8.
Kwizifundo zeklinikhi kumzimba womntu, ukusetyenziswa kwe-D-Arbutin kwiiveki ezili-12 kunokufezekisa iziphumo ezibalulekileyo zokukhanya kolusu, kwaye inefuthe elihle lokuphucula iindawo zokuvezwa kokukhanya kwemihla ngemihla kunye neemeko zolusu olumnyama.
Ixesha lokuposa: Jul-11-2023
