Yintoni iNattokinase?
I-Nattokinase (NK) yi-Bacillus subtilis protein kinase, i-serine protease eveliswa yi-Bacillus subtilis natto ngexesha lenkqubo yokuvundiswa kwe-natto. Inemisebenzi yokunyibilikisa amahlule egazi, ukunciphisa i-viscosity yegazi, ukuphucula ukujikeleza kwegazi, ukuthambisa kunye nokwandisa i-vascular elasticity.
Kwi-1980, kwafunyanwa kwi-Natto ukuba iqulethwe ngama-amino acid angama-275 ahlelwe ngendlela echanekileyo, kunye nobunzima be-molecular 27724. Inomsebenzi oyingqayizivele wokubola amahlule egazi, kwaye umphumo wayo osebenzayo umelwe yiyunithi ye-intrinsic FU.
Iimpawu zomzimba kunye neekhemikhali
I-Nattokinase ikhawuleza ijike kwaye iyeke ukusebenza kumaqondo obushushu angaphezulu kwe-80 ℃, kodwa ukunyibilika okuphindaphindiweyo akunasiphumo esincinci kuyo.
I-Nattokinase izinzile kwimizuzu eyi-10 xa ixabiso le-pH linyuka ukusuka kwi-7 ukuya kwi-12; Xa ixabiso le-pH lingaphantsi kwe-5, lijika ngokukhawuleza kwaye lingasebenzi.
Emva kokuxuba i-nattokinase ngezinto ezibonakalayo, inokugcina umsebenzi ongekho ngaphezu kwe-7.5% kwindawo ene-acidic enexabiso le-pH le-2-3.
I-Nattokinase yimolekyuli enkulu ye-peptidase yetsheyini enye enokwahlulwa ibe ngamaqhekeza e-amino acid okanye amatyathanga amancinci obunzima bemolekyuli ngejusi yokugaya amathumbu (i-chymotrypsin, i-trypsin, ulwelo lwamathumbu amancinci, njl.njl.).
Ixabiso lesondlo se-natto
INatto kukutya okusebenzayo okwenziwa ngeembotyi zesoya ezivundisiweyo ezivundiswe ziintsholongwane. Ukongeza ekugcineni izondlo zesoya eluhlaza, inamanqanaba aphezulu amacandelo athile anjengeprotein, ifayibha, icalcium, isinyithi, ipotassium, kunye neevithamini kuneembotyi zesoya eziphekiweyo.
Umxholo we-biotin B1, i-vitamin B2, kunye nezinye iiminerali, ngakumbi i-calcium, i-iron, kunye ne-potassium, ide igqithe amaqanda. Ukuba uthelekisa i-natto namaqanda kunye nenyama yenkomo, iprotein ye-100g ye-natto ilingana namaqanda ama-3 okanye i-80g yenyama yenkomo. Umxholo we-amino acid kwi-natto ucebile kakhulu, obangelwa ukuveliswa kweevithamini ezahlukeneyo kunye nee-enzymes ngexesha lenkqubo yokuvundisa, njenge-amylase, i-protease, i-lipase, i-cellulase, i-nattokinase, i-lysozyme, i-glutamic acid transpeptidase, njl. intshukumo yee-enzymes, iiprotheyini kunye nezinye izondlo zibola, ngoko ke izinga lokwetyisa kwe-natto (85%) liphezulu kunelo lembotyi yesoya ephekiweyo (68%), enezondlo kwaye kulula ukufunxa.
Uphando lwendima
I-NattoKinase (NK) yiprotheni ene-molecular weight encinci kakhulu kune-UK, SK, kunye ne-tPA, ekhutshwe kwi-natto yokutya okanye i-fermented yi-natto bacteria. Inokufunxwa ngamathumbu. I-in vitro kunye ne-in vivo thrombolytic properties ze-NK ziye zamiselwa ngokusebenzisa imifuniselo, kwaye kufunyenwe ukuba umsebenzi we-in vivo thrombolytic we-NK uphindwe kane kune-enzyme ye-fibrinolytic. Isebenza ngokukhawuleza kwaye ihlala ixesha elide kwi-vivo, kwaye inokwenza i-tPA isebenze emzimbeni, iyenze ibe mnene Ukuphucula ngokuqhubekayo umsebenzi we-fibrinolytic wegazi. Izigulane ezisengozini ye-myocardial infarction kufuneka zifake iiyunithi ze-300000 ze-urokinase ngexesha, kwaye i-50 grams ye-natto iqulethe iiyunithi ze-800000 ze-urokinase ye-thrombolysis.
Imisebenzi ephambili
isiphumo esibalulekileyo se-nattokinase sisebenza ngokukodwa ngokuchasene namahlwili egazi elidala. I-Nattokinase ifezekisa isiphumo esithe ngqo se-thrombolytic ngokufaka i-hydrolyzing eyona fibrin ye-thrombus, kwaye okwangoku kuphela kwento yendalo efunyenweyo ukunyibilikisa i-thrombus endala.
Kwi-2015, iYunivesithi yezoNyango yaseTokyo yenze uvavanyo lwe-thrombolytic nge-nattokinase ebantwini, eqinisekisa ukuba i-nattokinase inokuphucula amandla omzimba we-fibrinolytic kwaye ichithe ngempumelelo amahlule egazi. Ingxelo yophando inesihloko esithi "Idosi enye yomlomo we-nattokinase thrombolysis kunye nokuphuculwa kwe-anticoagulation" kwaye ipapashwe kwiiNgxelo zeNzululwazi ze-2015; 5: 11601.
Kwi-2016, kwi-48 iyure yokuhlola i-thrombolysis, i-300FU ye-nattokinase isetyenziswe kwi-thrombi endala kwiiyure ze-56, ebonisa ukuba i-thrombus yachithwa ngokupheleleyo kwiiyure ze-2; Isantya se-thrombolysis sokusebenzisa i-150FU nattokinase siphezulu kakhulu kunokusebenzisa ukulingana okufanayo kwe-urokinase [1]. Uphando lubonise ukuba i-nattokinase ayinayo impembelelo kwi-plasma fibrinogen, eyenza ukuba ingabikho lula ukopha. Inokuthi isebenze ngokufanelekileyo inkqubo ye-thrombolytic yomzimba, yenza umzimba ungakhuseleki kwi-thrombosis ngokusetyenziswa kwexesha elide, ngaloo ndlela iqinisekisa impilo yentliziyo kunye ne-cerebrovascular.
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Ixesha lokuposa: Sep-11-2023
