I-Kojic Acid Dipalmitate: Isisombululo sakho seNdalo sokuKhanya i-Melasma kunye ne-Age Spots
I-Kojic Acid Dipalmitate: Isisombululo sakho seNdalo sokuKhanya i-Melasma kunye ne-Age Spots
Kwiphulo lokufuna ulusu olungenasiphako nokukhanya, abantu abaninzi babhenela kwiimveliso ezahlukeneyo zokhathalelo kunye nonyango. Nangona kunjalo, ukufumana isisombululo esisebenzayo kunye nendalo sokukhanyisa imiba ye-pigmentation yesikhumba, efana ne-melasma kunye namabala ebudala, kunokuba ngumsebenzi onzima. Ngethamsanqa, kukho isithako esinamandla esinokukunceda ufezekise iziphumo ezifunwayo - i-Kojic Acid Dipalmitate.
I-Kojic Acid Dipalmitate, ekwaziwa njenge-ActiBiso-KDP, iphuma kwi-diesterized ye-kojic acid. I-asidi ye-Kojic ngokwayo yinto yendalo evundisiweyo kwaye ihlanjululwe kwi-glucose okanye i-sucrose phantsi kwesenzo se-Aspergillus. Eyona ndlela iphambili yokwenza mhlophe kukuthintela umsebenzi we-tyrosinase, i-enzyme ebandakanyekayo ekuvelisweni kwe-melanin, enika umbala kulusu lwethu. Ngaphezu koko, i-kojic acid dipalmitate yinto enqabileyo enye emhlophe enokuthi ivimbe ngexesha elinye i-enzymes ezininzi, kuquka i-N-hydroxyindoleic acid (DHICA) oxidase kunye ne-dihydroxyindole Indole (DHI) polymerization.
Nangona i-asidi ye-kojic ineempawu eziphawulekayo zokukhanyisa ulusu, iyakwazi ukuthotywa kunye nokungazinzi xa ibonakaliswe kwizinto ezifana nokukhanya, ubushushu, kunye nee-ion zetsimbi. Ngaphezu koko, amandla ayo okufunxwa lusu alinganiselwe. Ukoyisa le miceli mngeni, abaphandi baphuhlise izinto ezininzi eziphuma kwi-kojic acid ukomeleza ukusebenza kwesi sithako sinamandla.
I-Aogubio, inkampani ekhethekileyo ekuveliseni nasekuhanjisweni kwezinto ezisebenza nge-pharmacologically, imathiriyeli ekrwada, i-extracts yezityalo, kunye ne-nutraceuticals, ivelise imveliso yabo entsha - i-kojic acid dipalmitate, i-ActiBiso-KDP. Le mveliso yoguquko idibanisa iipropathi ezikhanyayo zesikhumba ze-kojic acid kunye nokuzinza kunye nokusebenza okuphuculweyo kwezinto eziphuma kuyo.
Esinye sezizathu zokuba i-kojic acid dipalmitate ifumene ukuthandwa kwimarike kukukwazi ukuthintela umsebenzi we-tyrosinase, ojongene nokuveliswa kwe-melanin esikhumbeni. Ngokunciphisa ukuveliswa kwe-melanin, i-kojic acid dipalmitate inceda ukucima kunye nokukhanyisa ukubonakala kwe-melasma kunye namabala eminyaka ubudala. Ukongeza, xa i-kojic acid dipalmitate idityaniswe ne-glucosamine derivatives, isiphumo sayo sokwenza mhlophe kwesikhumba sinyuka ngokukhawuleza.
Iingenelo zokusebenzisa i-kojic acid i-dipalmitate idlulela ngaphaya kweempawu zayo ezinamandla ezikhanyisa ulusu. Ikwasebenza njenge-antioxidant, inceda ukukhusela ulusu kumonakalo we-oxidative obangelwa yi-radicals yamahhala. Oku kuyenza ibe sisithako esifanelekileyo kwiimveliso ezichasene nokwaluphala, njengoko ayikhanyisi nje amabala amnyama kodwa ikwanceda ekugcineni ulusu olukhangeleka luselula kwaye lusempilweni.
Xa uqwalasela imveliso ye-skincare equlethe i-kojic acid dipalmitate, kubalulekile ukukhetha uphawu oluhloniphekileyo njenge-Aogubio. Ngobuchule babo ekuveliseni izinto ezisebenzayo ezikumgangatho ophezulu, izinto eziluhlaza, kunye nezicatshulwa zezityalo, i-Aogubio iqinisekisa ukusebenza kunye nokhuseleko lweemveliso zabo. Ukuzibophezela kwabo ekuhlangabezaneni neemfuno zamashishini amayeza, ukutya, isondlo, kunye nezithambiso kubonisa ukuzinikela kwabo ekuboneleleni izisombululo eziphezulu kubathengi.
Ukuqukumbela, ukuba usokola nemicimbi ye-pigmentation yesikhumba efana ne-melasma kunye namabala obudala, i-kojic acid dipalmitate sisisombululo sakho sendalo. Iimpawu zayo ezinamandla ezimhlophe, ezidityaniswa neziphumo zayo ze-antioxidant, ziyenza ibe lolona khetho lubalaseleyo lokufumana ulusu oluqaqambileyo nolunwenwe ngakumbi. Ngokukhetha i-Aogubio's ActiBiso-KDP, unokuqiniseka kumgangatho kunye nokusebenza kakuhle kwemveliso. Yithi ndlelantle kwithoni yesikhumba engalinganiyo kwaye molo kwibala elikhazimlayo kunye ne-kojic acid dipalmitate. Yamkela amandla endalo kwaye utyhile ubuhle bakho bokwenyani.
IiNkcazo zeeMveliso
I-Kojic acid dipalmitate iguqulwe i-kojic acid derivative, engapheleli nje ekoyiseni ukungazinzi kokukhanya, ubushushu kunye ne-ion yensimbi, kodwa igcina umsebenzi we-tyrosinase inhibitory kwaye inqanda ukubunjwa kwe-melanin. I-Kojic dipalmitate inepropati ezinzileyo yekhemikhali. Ayiyi kujika ibe tyheli kwi-oxidation, i-ion yensimbi, ukukhanyisa kunye nokufudumeza.
Umsebenzi
- i-kojic acid dipalmitate luhlobo oluthile lwe-inhibitor ye-melanin. Inokuthintela umsebenzi we-tyrosinase ngokudibanisa i-ion yobhedu kwiiseli emva kokuba ingene kwiiseli zesikhumba. I-asidi ye-Kojic kunye ne-derivative yayo inempembelelo engcono yokuthintela kwi-tyrosinase kunayo nayiphi na enye i-agent emhlophe yolusu.
- i-kojic acid dipalmitate inokuphelisa i-radical yasimahla, yomeleza umsebenzi weseli kwaye igcine ukutya kusitsha.
UPHICOTHO OLUYISISEKO
| UHLALUTYO | INGCACISO | IZIPHUMO |
| Imbonakalo | Umgubo oMhlophe | Iyahambelana |
| Ivumba | Uphawu | Iyahambelana |
| Wangcamla | Uphawu | Iyahambelana |
| Isivavanyi | 99% | Iyahambelana |
| Uhlalutyo lweSieve | I-100% iphumelele i-80 mesh | Iyahambelana |
| Ilahleko ekomisweni | 5% Ubuninzi. | 1.02% |
| Uthuthu lweSulfate | 5% Ubuninzi. | 1.3% |
| Ukukhupha i-Solvent | I-Ethanol kunye naManzi | Iyahambelana |
| Intsimbi enzima | 5ppm max | Iyahambelana |
| Njengoko | 2ppm max | Iyahambelana |
| Izinyibilikisi ezishiyekileyo | 0.05% Ubukhulu. | Ibi |
| IMicrobiology | ||
| Ubalo lwePleti lulonke | 1000/g Ubuninzi | Iyahambelana |
| Igwele kunye noMngundo | 100/g Ubuninzi | Iyahambelana |
| E.Coli | Ibi | Iyahambelana |
| Salmonella | Ibi | Iyahambelana |
Usetyenziso
Iitoni zokunyamekela umzimba/ubuso, amalungiselelo okulwa nokuguga, ukukhuselwa kwelanga, emva kokutshiswa lilanga kunye nokuzitshisa, ukwenza mhlophe ulusu/ukukhanya, unyango lweentlobo ngeentlobo zeemeko zolusu lwe-hyperpigmentation okanye iziphazamiso, umz. i-solar lentigenes, i-melasma, i-chloasma, ama-scars, ama-freckles, ubudala bebala kunye neminye imimandla yesikhumba hyperpigmented
