I-Kojic Acid Dipalmitate vs. ezinye izithako ezikhanyisa ulusu
I-Kojic Acid Dipalmitate vs. Ezinye izithako eziKhanyayo zolusu: Isisombululo se-Aogubio esitsha
I-Aogubio, inkampani ekhethekileyo ekuveliseni nasekuhanjisweni kwezinto ezisebenzayo ze-pharmacological, izinto eziluhlaza, kunye nezicatshulwa zezityalo, zihamba phambili ekuphuhlisweni kweemveliso eziqhekezayo kumashishini ahlukeneyo. Enye yezinto ezintsha eziphawulekayo yi-Kojic Acid Dipalmitate (KAD-15), isithako esinamandla sokukhanyisa isikhumba esibeka umgangatho omtsha kwintsimi. Kweli nqaku, siza kuphonononga izibonelelo ze-KAD-15 xa kuthelekiswa nezinye izithako ezikhanyisa ulusu, ziqaqambise ukusebenza kwayo, ukuzinza kunye nokhuseleko.
I-Kojic Acid Dipalmitate yifomula ephucukileyo kakhulu xa kuthelekiswa nezithako ezikhanyisa ulusu zemveli ezifana ne-arbutin kunye ne-kojic acid. Ngelixa ezi zithako zisetyenziselwe iipropathi zazo ezimhlophe, i-KAD-15 ibonelela ngenqanaba eliphezulu lokusebenza. Isebenza ngokuthintela umsebenzi we-tyrosinase, ojongene nokwakhiwa kwe-melanin esikhumbeni. Ngokuthintela umsebenzi wale enzyme, i-KAD-15 inciphisa ngempumelelo imveliso ye-melanin kwaye emva koko ikhanyise ithoni yesikhumba.
Enye inzuzo ephawulekayo ye-KAD-15 lizinga layo elikhethekileyo lokusebenza, elingaphezulu kwe-80%. Eli zinga libalaseleyo liqaqambisa amandla ayo kwaye liyibeke ngaphandle kwezinye izithako ezikhanyisa ulusu. Ngokusebenza kwayo okuphezulu, i-KAD-15 iqinisekisa iziphumo ezibonakalayo kunye nexesha elide, ukubonelela abathengi ngesisombululo esisebenzayo kwiimfuno zabo zokukhanya kwesikhumba.
Uzinzo ngomnye umba obalulekileyo omawuqwalaselwe xa uvavanya izithako ezikhanyisa ulusu. Inqaku le-KAD-15 ngokukhethekileyo kulo mba, linikezela ngoqulunqo oluzinzileyo olugcina iimpawu zayo ngokuhamba kwexesha. Ngokungafaniyo nezinye izithako ezinokuthi zithobe okanye zibe namandla kancinci ekuhambeni kwexesha, i-KAD-15 igcina ukusebenza kwayo, iqinisekisa iziphumo ezihambelanayo nezithembekileyo. Oku kuzinza kububungqina bokuzinikela kuka-Aogubio ekuhambiseni iimveliso ezikumgangatho ophezulu.
Ngapha koko, ukhuseleko lubaluleke kakhulu xa kuziwa kwiimveliso zokhathalelo lwesikhumba. Nge-KAD-15, abathengi banokunandipha uxolo lwengqondo, njengoko luphuhliswe ngokucophelela ukuhlangabezana nemigangatho ephezulu yokhuseleko. I-Aogubio iqinisekisa ukuba zonke iimveliso zabo, kuquka i-KAD-15, zivavanywa ngokuqatha kunye namanyathelo okulawula umgangatho ukuqinisekisa ukhuseleko lwabo lokusetyenziswa kwabantu. Oku kuzibophelela kukhuseleko kunabela kuwo onke amashishini, kubandakanywa icandelo lamayeza, ukutya, isondlo, nezokuthambisa.
Ngaphaya koko, i-KAD-15 inokudityaniswa ngokubambisana nezinye izithako ezikhanyisa ulusu, ezinje nge-vitamin C ethyl ether kunye ne-arbutin. Esi siphumo sekhompawundi esisodwa siphucula isiphumo esimhlophe esipheleleyo, sivumela iziphumo ezingcono. Ngokubandakanya i-KAD-15 kwindlela yabo yokunakekelwa kwesikhumba, abasebenzisi banokufumana indlela ebanzi kunye neyongezelelweyo yokukhanya kwesikhumba.
Ukuqukumbela, i-Aogubio's Kojic Acid Dipalmitate (KAD-15) imele ukuqhubela phambili okubonakalayo kwintsimi yezithako ezikhanyisa ulusu. Ngokusebenza kwayo okuphezulu, ukuzinza, kunye nokhuseleko, idlula iinketho zemveli ezifana ne-arbutin kunye ne-kojic acid. Ngokukwazi ukuvimbela umsebenzi we-tyrosinase kunye nebhlokhi yokubunjwa kwe-melanin, i-KAD-15 inikeza iziphumo ezibonakalayo kunye nexesha elide. Ukuzinikela kwe-Aogubio kumgangatho kunye nokutsha kuqinisekisa ukuba i-KAD-15 ihlangabezana neyona migangatho iphezulu yokhuseleko, iyenza ibe lukhetho oluthembekileyo kumashishini amayeza, ukutya, isondlo kunye ne-cosmetic. Ngokubandakanya i-KAD-15 kuqulunqo lwabo, iinkampani zinokunika abathengi bazo isisombululo esikhethekileyo nesisebenzayo kwiimfuno zabo zokukhanya kolusu.
IiNkcazo zeeMveliso
I-Kojic acid dipalmitate iguqulwe i-kojic acid derivative, engapheleli nje ekoyiseni ukungazinzi kokukhanya, ubushushu kunye ne-ion yensimbi, kodwa igcina umsebenzi we-tyrosinase inhibitory kwaye inqanda ukubunjwa kwe-melanin. I-Kojic dipalmitate inepropati ezinzileyo yekhemikhali. Ayiyi kujika ibe tyheli kwi-oxidation, i-ion yensimbi, ukukhanyisa kunye nokufudumeza.
Umsebenzi
- i-kojic acid dipalmitate luhlobo oluthile lwe-inhibitor ye-melanin. Inokuthintela umsebenzi we-tyrosinase ngokudibanisa i-ion yobhedu kwiiseli emva kokuba ingene kwiiseli zesikhumba. I-asidi ye-Kojic kunye ne-derivative yayo inempembelelo engcono yokuthintela kwi-tyrosinase kunayo nayiphi na enye i-agent emhlophe yolusu.
- i-kojic acid dipalmitate inokuphelisa i-radical yasimahla, yomeleza umsebenzi weseli kwaye igcine ukutya kusitsha.
UPHICOTHO OLUYISISEKO
| UHLALUTYO | INGCACISO | IZIPHUMO |
| Imbonakalo | Umgubo oMhlophe | Iyahambelana |
| Ivumba | Uphawu | Iyahambelana |
| Wangcamla | Uphawu | Iyahambelana |
| Isivavanyi | 99% | Iyahambelana |
| Uhlalutyo lweSieve | I-100% iphumelele i-80 mesh | Iyahambelana |
| Ilahleko ekomisweni | 5% Ubuninzi. | 1.02% |
| Uthuthu lweSulfate | 5% Ubuninzi. | 1.3% |
| Ukukhupha i-Solvent | I-Ethanol kunye naManzi | Iyahambelana |
| Intsimbi enzima | 5ppm max | Iyahambelana |
| Njengoko | 2ppm max | Iyahambelana |
| Izinyibilikisi ezishiyekileyo | 0.05% Ubukhulu. | Ibi |
| IMicrobiology | ||
| Ubalo lwePleti lulonke | 1000/g Ubuninzi | Iyahambelana |
| Igwele kunye noMngundo | 100/g Ubuninzi | Iyahambelana |
| E.Coli | Ibi | Iyahambelana |
| Salmonella | Ibi | Iyahambelana |
Usetyenziso
Iitoni zokunyamekela umzimba/ubuso, amalungiselelo okulwa nokuguga, ukukhuselwa kwelanga, emva kokutshiswa lilanga kunye nokuzitshisa, ukwenza mhlophe ulusu/ukukhanya, unyango lweentlobo ngeentlobo zeemeko zolusu lwe-hyperpigmentation okanye iziphazamiso, umz. i-solar lentigenes, i-melasma, i-chloasma, ama-scars, ama-freckles, ubudala bebala kunye neminye imimandla yesikhumba hyperpigmented
