Yintoni iPROCYANIDIN B-2 (ecatshulwe kwii-apile)?

Yintoni leya?

I-Procyanidin B-2, i-subclass ye-flavonoids eyaziwayo ukuba isebenzise i-antioxidant enamandla, unyango, kunye nemiphumo echasayo.

Ezi khompawundi ze-polyphenol, eziqhelekileyo ezifumaneka kwiiapile, ibhali, kunye nembewu yomdiliya, ziye zacetyiswa ukuba zivelise ukukhula kweenwele imiphumo ekhuthazayo ngokukhuthaza ukukhula kweeseli ze-epithelial kunye nokunyanzeliswa kwesigaba sokukhula kwe-anagen esebenzayo kwiimodeli ze-vivo murine kunye ne-6 inyanga kunye ne-12 inyanga yeklinikhi. izilingo.

Iinzuzo zeI-PROCYANIDIN B-2

Izenzo zokuthintela ngokuchasene nophuhliso lwe-catagen, ukutshatyalaliswa kwe-DNA yeselula (i-apoptosis), kunye nokulahleka kweenwele:

Olu pho nonongo luhlolisise ubudlelwane beProcyanidin b-2 kwiindlela ze-TGF-beta zesignali, ezaziwa ngokubangela isigaba se-catagen (esiyinqanaba leenwele eziphazamisayo), kunye ne-mitogen-activated protein kinase cascade (PKC), edityaniswe neseli. ukwanda. Olu phononongo longeze i-TGF-beta (1) kunye (2) kwiinkcubeko zeseli ye-epithelial yeenwele kwaye yaphawula ukuba ezi ndlela zedosi zixhomekeke ekukhuleni kweeseli kunye ne-apoptosis ebangela i-apoptosis (i-apoptosis kukufa kweeseli okwenzeka njengesiqhelo kunye nenxalenye elawulwayo. ukukhula okanye ukukhula kwezinto eziphilayo). Nangona kunjalo, ukongezwa kwe-procyanidin B-2 kwinkcubeko yeseli yeenwele kuthintele ezi ziphumo zokuthintela ukukhula kwaye zikhusele iiseli zeenwele kwi-apoptosis.

Zingaphezulu kwe-1,000 izicatshulwa zendalo eziye zavavanywa...

Iproanthocyanidins (kubandakanya iprocyanidin b-2) evela kwisicatshulwa sembewu yomdiliya yathathwa njengesicatshulwa sendalo esibalulekileyo sokukhula kweenwele, emva kokuba izazinzulu zivavanye ngaphezulu kwe-1,000 yeentlobo ezahlukeneyo zezityalo. Baye bafumanisa ukuba ezi proanthocyanidins zandisa iiseli ze-follicle zeenwele kwiimpuku malunga ne-230% ngokumalunga nolawulo (100%) kwaye ziphethe "umsebenzi omangalisayo wokuguqula iinwele ukusuka kwisigaba se-telogen ukuya kwisigaba se-anagen ...". Ngoko ke kuhlalutyo lwe-1,000 kwiincindi zezityalo, imbewu yomdiliya igqwesile kuzo zonke. Iziqulatho kwiincindi zembewu yomdiliya kunye nesizathu sabo sokuphumelela ekukhuleni kweenwele zixutywa ngeendlela ezahlukeneyo ze-phenolic compounds, amandla e-antioxidant, ukuphuculwa kokujikeleza kwegazi, ukukhuthazwa kwe-collagen kunye nezinye izibonelelo. (isifundo). Izicatshulwa zembewu yomdiliya zenza iindidi ze oligomeric proanthocyanidins ezimalunga ne 3.1% ye PB-2 kuphela. Sifuna umxholo ongaphezulu we-PB-2, ngoko ke izicatshulwa zembewu yeediliya azinamdla wokukhula kweendevu (nangona zisenokuba zezokukhula kweenwele).

Iimpembelelo zokuKhula kweeseli zeNwele ze-Epithelial

Ukuqukumbela kwindlela yokukhuthaza ukukhula kwezi procyanidins, olu phononongo lubonise ukuba iprocyanidin b-2 ibonise iziphumo eziphezulu zokunyusa ukukhula kweenwele ze-epithelial cell. Olu phando lubonisa ukuba i-procyanidin b-2 inomsebenzi wokukhuthaza ukukhula kwiiseli ze-urine hair epithelial kwinqanaba eliphezulu le-300% ngokumalunga nokulawula kwinkcubeko yosuku lwe-5, kwaye ibonise ukuba i-procyanidin oligomers ivuselela i-anagen induction kwi-vivo murine. imodeli phantse ukuqina efanayo njengoko minoxidil 2%. I-Procyanidin b-2 yagqama njengeyona polyphenol ephezulu yokukhuthaza ukukhula, xa kuthelekiswa ne-PB-3 kunye ne-PC-1 (yiyo loo nto isicatshulwa sembewu yomdiliya asiyi kuba ngowona mthombo wokukhula kweendevu).

Kuyathakazelisa ukuqaphela ukuba olu phononongo luphonononge kuphela ukusetyenziswa kwesihloko kwezi oligomers zeprocyanidin kunye noxinzelelo lwe-1%. Olu phononongo luthelekisa kuphela i-1% yoxinaniso kunye ne-minoxidil 2%. Inokuthi ichazwe ukuba i-concentration ephezulu (njenge-5%) ye-procyanidin b-2 inokuthelekisa ngokufanelekileyo kunye ne-Minoxidil 5%.

Olu pho nonongo lubonisa amandla athembisayo okuba iprocyanidin b2 isetyenziswe njengento ebangela ukukhula kweenwele zendalo.

Iimvavanyo zoNyango lwaBantu

Olu vavanyo lweklinikhi luphande imiphumo ye-1% ye-procyanidin b2 kuphela ekukhuleni kweenwele zomntu emva kokusetyenziswa kweenyanga ze-6. Uvavanyo lweklinikhi oluyimfama oluphindwe kabini olubandakanya izifundo ze-29 zizonke zenziwa. Amadoda angama-19 kwiqela le-procyanidin B-2 kunye namadoda angama-10 kwiqela lokulawula i-placebo aphantsi kohlalutyo. Akukho miphumo emibi ibonwe kulo naliphi na iqela.

Iziphumo:

Ukunyuka kwenani leenwele ezipheleleyo kwindawo echongiweyo ye-scalp (0.5 cm square = 0.25 cm2 indawo) yeqela leqela le-procyanidin B-2 emva kovavanyo lweenyanga ze-6 lwalukhulu kakhulu kuneqela leqela le-placebo (iprocyanidin B-2). , 6.68 +/- 5.53 (ithetha +/- SD)/0.25 cm2, 0.08 +/- 4.56 (ithetha +/- SD)/0.25 cm2; Ukunyuka kwenani leenwele ze-terminal, ezichazwa njengeenwele ezingaphezu kwe-60 microm ububanzi, kwindawo echongiweyo (0.5 cm square = 0.25 cm2 indawo) yezifundo zeqela le-procyanidin B-2 emva kovavanyo lweenyanga ze-6 lukhulu kakhulu. kunaleyo yezifundo zeqela le-placebo (procyanidin B-2, 1.99 +/- 2.58 (ithetha +/- SD)/0.25 cm2; indawo, -0.82 +/- 3.40 (ithetha +/- SD)/0.25 cm2; P

Ezi ziphumo zityhila ukuba amadoda asebenzise i-PB2 ayenokwanda okukhulu kweenwele ezipheleleyo ezikhulileyo, inani leenwele ze-terminal, kwaye akukho ziphumo bezingalindelekanga zichaziweyo.

Xa abaphandi bethelekisa iziphumo zabo kunye namayeza akhoyo ngoku, bafumanisa ukuba i-procyanidin B-2 ibangele ukukhula kweenwele ezincinci kune-minoxidil (kwi-2%, kungekhona i-5%), kodwa ukwanda kweenwele ezipheleleyo kune-finasteride (Proscar). Ngokungafaniyo nala mayeza kagqirha, iprocyanidin B-2 ayizange ivelise iziphumo ebezingalindelekanga. Unyango lwe-Procyanidin B-2 lubonisa okunokwenzeka njengonyango olukhuselekileyo noluthembisayo lwempandla yamadoda.

Olunye uphononongo lwezonyango, oluthathe iinyanga ezili-12, luphande ukusebenza kwe-0.7% ye-apula procyanidin oligomers (kwakhona, ugxininiso oluphantsi kodwa iziphumo zisabalulekile).

Uvavanyo lweklinikhi oluyimfama oluphindwe kabini olubandakanya izifundo ze-43 zizonke zenziwa. Amadoda angama-21 kwiqela le-procyanidin kunye namadoda angama-22 kwiqela lokulawula i-placebo aphantsi kohlalutyo. Kwiinyanga zokuqala ze-6, sithelekisa iprocyanidin kunye namaqela e-placebo ukuvavanya imiphumo yonyango ye-procyanidin oligomers. Ixesha lesicelo seqela leprocyanidin landiswa emva koko ukuya kwiinyanga ze-12, kwaye ixesha lexabiso lokulungiswa kwayo lihlolwe.

Ukunyuka kwenani elipheleleyo leenwele kwindawo echongiweyo ye-scalp yezifundo zeqela le-procyanidin emva kovavanyo lweenyanga ze-6 lwalukhulu kakhulu kunezifundo zeqela le-placebo (procyanidin, 3.3 +/- 13.0 (ithetha +/- SD)/ 0.50 cm (2), -3.6 +/- 8.1/0.50 cm (2); Uphuculo oluxhomekeke kwixesha elixhomekeke kubuninzi beenwele lwabonwa kwizifundo zeprocyanidin. Akukho miphumo emibi ebonwe kuyo nayiphi na izifundo. Unyango lweProcyanidin ngaloo ndlela lubonisa umsebenzi onokukhula kweenwele.

I-Pharmacology & Pharmacokinetics yeProcyanidin B-2

I-Pharmacology lisebe leyeza elijongene nokusetyenziswa, iziphumo, kunye neendlela zokwenza amachiza.

I-Pharmacokinetics lisebe le-pharmacology elijongene nokuhamba kwamachiza ngaphakathi komzimba.

Akubalulekanga kuphela ukujonga kunye nokuhlalutya iindlela zesenzo se-PB-2, kubalulekile ukujonga ukuba esi sithako sinokufunxwa njani, singene, kwaye sifumaneke ngokwebhayoloji xa sisetyenziswa ngokwezihloko.

Olu phononongo luqwalasele ukungena kwe-percutaneous kwe-PB2 kwiloshini ene-0.0663mg kuphela. Iziphumo zabonisa ukuba ngaphandle kokuxinana okuphantsi kwi-lotion, i-substance ibonakalise iluncedo malunga ne-pharmacokinetics.

Ithiyori ye-4-5% yoxinaniso lwe-PB2 kufuneka lunikezele kwaye lungene ngokufanelekileyo, kodwa i-chemist ye-cosmetic endiyiqeshileyo iya kundiqinisekisa ukuba oku kunokwenzeka.

Ngaba oku akunatyhefu kwaye kukhuselekile ukusetyenziswa?

Ukuvavanya ukhuseleko lwe-topical procyanidin B-2 njenge-agent ekhulayo yeenwele, olu phononongo luhlolisise i-mutagenicity, i-acute subcutaneous injection, ukucaphuka okuphambili, ukuvuselela ulusu, kunye nokucaphuka kwamehlo ale khompawundi. Iziphumo zabonisa le khompawundi ukuba ayinazo iziphumo ze-mutagenic, i-structural aberrations, idosi esemthethweni ingaphezulu kwe-2000mg (inaliti engaphantsi kwe-cutaneous), akukho ukucaphuka okuphambili phakathi kovavanyo kwimivundla, kunye nokucaphuka okuncinci xa kufakwe emehlweni omvundla.

Ulingo lwangaphambili lweklinikhi ebantwini nalo alubonisi iziphumo ezibi ezibikiweyo. Izifundo ezikhankanywe ngaphambili kwiimodeli ze-murine zibonise ukuba akukho miphumo emibi.

Ezi ziphumo zibonisa ukuba i-topical procyanidin b-2 ikhuselekile kwaye yamkelekile ukusetyenziswa.

Ukuqukumbela, iProcyanidin B-2 inamandla amakhulu kwaye isoloko iphononongwa ngenxa yeenzuzo zayo ezininzi zempilo. Ukuzinikela kuka-Aogubio ekuphuhliseni i-nutraceuticals, izongezo kunye neemveliso kumashishini ahlukeneyo asebenzisa i-Procyanidin B-2 igxininisa ukuzinikela kwenkampani ekusebenziseni amandla ezinto zendalo ukuphucula impilo yabantu. Njengoko uphando kunye nokuqonda kweProcyanidin B-2 kuqhubeka nokuguquka, kuyacaca ukuba iProcyanidin B-2 enamandla ibambe isithembiso esikhulu kwikamva lempilo yendalo.

Miranda Zhang